Enemies come in various forms and sizes. These can be FBC rangers controlled by the Hiss, infected mold hosts and even Object of Powers controlled by the Hiss. Some enemies can have shields and also can have various weapons like rifles and shotguns. Each enemy has a certain level which is displayed above their health bar.
List of Enemy Types
The Hiss
| Enemy | Image | Weapons |
|---|---|---|
| Hiss Agent | 
|
|
| Hiss Charged | 
|
|
| Hiss Cluster | 
|
|
| Hiss Demolition Expert | 
|
Rifle Grenade |
| Hiss Distorted | 
|
|
| Hiss Elevated | 
|
|
| Hiss Guard | 
|
M43 Rifle
Serbu Super Shorty |
| Hiss Ranger | 
|
Submachine Gun
M43 Rifle NeoStead |
| Hiss Ranger (Airborne) | 
|
Submachine Gun
M43 Rifle NeoStead |
| Hiss Sharpened | 
|
|
| Hiss Sniper | 
|
Sniper Rifle |
| Hiss Trooper | 
|
Grenade Launcher
Minigun |
| Hiss Warped | 
|
Astral Entities
| Enemy | Image | Weapons |
|---|---|---|
| Astral Copy | 
|
Submachine Gun
M43 Rifle NeoStead |
| Astral Mimic | 
|
|
| Astral Spike | 
|
|
| Golden Copy | 
|
Submachine Gun
M43 Rifle NeoStead |
Mold Entities
| Enemy | Image |
|---|---|
| Mold Host | 
|
| Mold Host-Ranged | 
|
List of Bosses
| Boss | Image |
|---|---|
| Alberto Tommasi | |
| Emil Hartman | 
|
| esseJ | 
|
| Former | 
|